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Mild Kidney Disease Tied to Pregnancy Risk

A comparison of 504 women with various stages of chronic kidney disease with 836 of a well-matched cohort revealed:

in women with stage 1 CKD, the rate of caesarean section was 8.4% vs 70.1% for stage 2, 78.4% for stage 3, and 70.0% for stages 4 to 5 (P < .001).

Preterm delivery rate was 23.5% for stage 1 vs 50.6% for stage 2, 78.4% for stage 3, and 88.9% for stages 4 to 5 (P < .001).

NICU (neonatal intensive care unit) rates by stage were 10.3%, 27.6%, 44.4%, and 70.0% (P < .001).

[small size at birth] SGA (<10%) by stage was 13.3%, 17.9%, 18.9%, and 50.0% (P = .023).

General combined outcome ranged from 34.1% to 90.0% (P < .001), and severe combined outcome from 21.4% 80.0% (P < .001).

New-onset maternal hypertension ranged from 7.9% in stage 1 to 50.0% in stages 4 to 5 (P < .001).

New-onset or doubling of proteinuria was 20.5% in stage 1 and 70.0% in stages 4 to 5 (P < .001).

 

**Just a reminder: Stage 1 chronic kidney disease is GFR < 80 while Stage 3 is GFR < 60. Many living kidney donors find themselves in Stage 3 only a few years post-donation.**

 
Piccoli GB, Cabiddu G, Attini R, Vigotti FN, Maxia S, Lepori N, Tuveri M, Massidda M, Marchi C, Mura S, Coscia A, Biolcati M, Gaglioti P, Nichelatti M, Pibiri L, Chessa G, Pani A, & Todros T (2015). Risk of Adverse Pregnancy Outcomes in Women with CKD. Journal of the American Society of Nephrology : JASN PMID: 25766536

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